Samsca® (tolvaptan) – the first and only oral vasopressin antagonist Samsca is a selective vasopressin V2-receptor antagonist with an affinity for the V2 receptor which is greater than that of the native arginine vasopressin. Samsca® is an original drug from Otsuka which is included in the drug class known as vasopressin antagonists (vaptans). Samsca® is approved by the EMA (European Medicines Agency) for the treatment of hyponatremia secondary to SIADH.

  1. SmPC